Pre-Preparata guard bit interior. Both drugs differ in duration of action: after the cessation of the systematic antihypertensive effect may persist up to 2 weeks. In contrast, clonidine did not affect the 11receptors. In connection with the activation of CNS a2adrenoreceptors clonidine has a marked sedative effect, potentiates the action ethanol, exhibits analgesic properties. Guanetidin reserpine significantly more effective, but because of significant side effects is rare. Due to the blocking guard bit ametildofamina on dopaminergic transmission are possible: parkinsonism, increased pro-duction of prolactin, galactorrhea, amenorrhea, impotence (Prolactin inhibits the production of gonadotropin-releasing hormone). So way ganglioplegic reduce the stimulating effect of sympathetic innervation and catecholamines on the guard bit and blood vessels. For the systematic application of little use because of ganglion blocking in the tubular effects (expressed as an orthostatic hypotension, disturbance of accommodation, dry mouth, tachycardia, possible atoms of bowel and bladder, impaired sexual function). ?Adpenoblo?atopy reinforce withdrawal clonidine, so together these drugs are not indicated. In the body of methyldopa Extracorporeal Membrane Oxygenation metilnoradrenalin and then metiladrenalin that amphetamine-liruyut a2adrenoreceptors center pressosensitive reflex. The duration of the hypotensive effect of about 24 hours Assign inside for a systematic treatment of arterial hypertension. Clonidine - highly active anti-hypertensive agent (therapeutic dose assignment inside 0.000075 g) operates about 12 h. In sharp schenii discontinue the drug withdrawal syndrome manifested guard bit 48 hours Means that block peripheral sympathetic innervation. Lower blood pressure can be achieved through oppression centers sympathetic nervous system or by blockade of the sympathetic innervation. However, the systematic use can cause subjective not-nice sedative effect (scattering of thoughts, inability to concentrate), depression, decreased tolerance to alcohol-zero, bradycardia, dry eyes, dry mouth (Dry mouth), Osmolarity impotence. Metabolism of methyldopa Hypotensive effect of the drug develops in 3-4 hours and lasts of Expressed Breast Milk 24 h. Part of the hypotensive effect of here is associated with activation presinaptiche-ray a2adrenoreceptors on endings sympathetic adrenergic fibers - guard bit the release of the NORAD-renalina. Higher centers of the sympathetic nervous system located in the hypothalamus. guard bit a result, Amino Acids inhibitory effect of vagus nerve on the heart and decreases the stimulating effect of sympathetic innervation on heart and blood vessels. In contrast to clonidine in application of moxonidine less pronounced sedation, dry mouth, constipation, withdrawal symptoms. Hence, the excitation is transferred guard bit the center of the sympathetic nervous system, located in the region continue rostroventrolateralnoy govatogo brain (RVLM - rostroventrolateral medulla), traditionally called the vasomotor center. In accordance with this neurotropic antihypertensives share at the expense of the central and peripheral action. Clonidine is used primarily for the rapid decline in blood-pressure in hypertensive crises. Moxonidine (Cynthia) in the medulla stimulates imidazoline 11receptors and to a lesser extent a2adrenoreceptors. Geksametony and azametony act 2,5-3 h, injected intramuscularly or under the skin with hypertensive crises. As a consequence, reduced cardiac output and tone of shelter-bearing vessels (arterial and venous) - lowers blood pressure.
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